Interferon regulatory factor 4 and 8 in B-cell development
نویسندگان
چکیده
منابع مشابه
IRF4 (interferon regulatory factor 4)
Other names: IRF-4; NF-EM5; LSIRF (lymphocytespecific interferon regulatory factor); MUM1 (multiple myeloma oncogene 1) HGNC (Hugo): IRF4 Location: 6p25.3 Local order: IRF4 is located on chromosome 6 at the telomeric extremity of the short arm, and lies between the DUSP22 (dual specificity phosphatase 22) and EXOC2 (exocyst complex component 2) genes. Note: IRF4 belongs to the IRF (interferon r...
متن کاملIFN regulatory factor-4 and -8 govern dendritic cell subset development and their functional diversity.
Dendritic cells (DCs) are bone marrow (BM)-derived APCs central to both innate and adaptive immunity. DCs are a heterogeneous cell population composed of multiple subsets with diverse functions. The mechanism governing the generation of multiple DC subsets is, however, poorly understood. In this study we investigated the roles of closely related transcription factors, IFN regulatory factor (IRF...
متن کاملHematopoietic interferon regulatory factor 8-deficiency accelerates atherosclerosis in mice.
OBJECTIVE Inflammatory leukocyte accumulation drives atherosclerosis. Although monocytes/macrophages and polymorphonuclear neutrophilic leukocytes (PMN) contribute to lesion formation, sequelae of myeloproliferative disease remain to be elucidated. METHODS AND RESULTS We used mice deficient in interferon regulatory factor 8 (IRF8(-/-)) in hematopoietic cells that develop a chronic myelogenous...
متن کاملActivation of IL-27 p28 gene transcription by interferon regulatory factor 8 in cooperation with interferon regulatory factor 1.
Interferon regulatory factor (IRF) family members, especially interferon regulatory factor-1 (IRF-1) and interferon regulatory factor-8 (IRF-8 or ICSBP), play important roles in interferon signaling in a wide range of host responses to infection and tumor growth. Interleukin-27 (IL-27), as a member of the IL-12 cytokine family, not only acts as a proinflammatory cytokine that regulates the diff...
متن کاملInterferon regulatory factor 4 is involved in Epstein-Barr virus-mediated transformation of human B lymphocytes.
Epstein-Barr virus (EBV) infection is associated with many human malignancies. In vitro, EBV transforms primary B lymphocytes into continuously growing lymphoblastoid cell lines. EBV latent membrane protein 1 (LMP-1) is required for EBV transformation processes. Interferon regulatory factor 4 (IRF-4) is a transcription factor and has oncogenic potential. We find that high levels of IRF-4 are as...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Trends in Immunology
سال: 2008
ISSN: 1471-4906
DOI: 10.1016/j.it.2008.07.006